GLP-1 Use & Postpartum: What New Mums Need to Know
Life after birth is full of change — emotionally, physically, hormonally. If you’ve been prescribed a GLP-1 medication (like Wegovy® or Mounjaro®), you’re likely aware of many benefits. But postpartum adds extra complexity: reduced appetite, recovery from childbirth, hormonal shifts, breastfeeding (if you choose), and a body that’s still healing.
Unfortunately, formal guidance on GLP-1s in the postpartum period is limited. Most clinical trials exclude people who are breastfeeding, and there are very few studies focused specifically on new mums. This leaves many in a grey zone — wanting to use GLP-1s for weight-related benefits but unsure about safety, timing, and how to make it work in real life.
Here’s what the current evidence suggests — and where questions remain.
📊 What Studies Tell Us (So Far)
Semaglutide & Breastfeeding
A small study of eight women who were breastfeeding found no detectable levels of injectable semaglutide in breast milk, and no adverse effects in infants were reported. However, the researchers stressed the need for larger trials before safety can be confirmed.
→ News Medical, 2024Medication Safety Labels
Most GLP-1 medicines are labelled “not recommended during lactation” because of the lack of human data. Safety profiles rely heavily on animal studies or very small human cohorts.
→ American Academy of Family Physicians, 2022Pregnancy / Peri-conception
Animal studies of GLP-1 agonists have shown risks such as reduced fetal survival and delayed bone growth. Human pregnancy data is sparse, so current guidance is to avoid use while pregnant or trying to conceive.
→ Springer Review, 2024General Lactation Safety
Early findings suggest injectable GLP-1s are unlikely to pass into milk at significant levels, but the long-term effects of even trace exposure are unknown.
→ News Medical, 2024
🧠 GLP-1s, Anxiety & Depression Postpartum
The postpartum period already carries a higher risk of mood changes, including postpartum depression and anxiety. Sleep deprivation, hormonal shifts, and the emotional adjustment to life with a newborn can all play a role.
Some research has raised questions about whether GLP-1 medications may influence mood. A large cohort study found an increased risk of depression, anxiety, and suicidal behaviour among GLP-1 users compared to non-users【Nature, 2024】. On the other hand, other studies and patient reports suggest that many people feel mood improvements as appetite stabilises, weight decreases, and metabolic health improves【PMC Review, 2023】.
Because the data is mixed — and virtually no studies focus specifically on postpartum mums — it’s important to monitor your mental health closely if you’re using a GLP-1 after birth. If you notice changes in mood, speak with your GP or prescriber promptly. Supportive community, nutrition, gentle activity, and rest can also help balance both physical and emotional wellbeing.
⚠️ Gaps in Knowledge
How GLP-1s affect milk production or composition.
Whether small traces in breast milk affect infant development.
Optimal timing for starting GLP-1s postpartum if not breastfeeding.
How postpartum hormone shifts interact with GLP-1 dosing and side effects.
Long-term impacts on mental health during postpartum recovery.
💡 Practical Tips for Postpartum Mums on GLP-1s
Discuss treatment timing with your prescriber, especially if you’re breastfeeding or planning to.
Monitor fatigue — it may be both postpartum and medication-related.
Keep track of your mood and emotional wellbeing; raise concerns early.
Prioritise protein, hydration, gentle movement, and rest when possible.
If prescribed, increase doses gradually and only under supervision.
Build emotional support — sleep disruption, appetite changes, and pressure to “bounce back” can feel overwhelming.
FAQs: GLP-1 Medications & Postpartum
Check out more FAQs HERE
✨ Final Thoughts
GLP-1s offer real promise for weight management and metabolic health, but postpartum requires extra care. With limited research, the safest approach is one tailored to your body, your recovery, and ongoing medical advice.
For practical tools and community support, the GLPReset Hub offers free resources, blog guides, and newsletters. Members also get access to weekly live sessions, private WhatsApp groups, structured meal plans, and our OutfitXchange™ clothes swap service — helping you feel supported at every stage of the journey.
📌 Disclaimer: This article is for information only and does not replace professional medical advice. Always consult a qualified prescriber before starting or changing medication, especially during pregnancy or breastfeeding.